Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | APP | P05067 | 3/20 | 0.34 |
| ▸ | SNCA | P37840 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 6/20 | 0.34 |
| ▸ | RARG | P13631 | 6/20 | 0.34 |
| ▸ | RXRA | P19793 | 6/20 | 0.34 |
| ▸ | RARA | P10276 | 5/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027547 | 0.85 | ALDH1A1 (0.36) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL5333849 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL9215852 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL9215847 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL26428237 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL26428189 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL9209366 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL9749046 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL8388735 | 0.81 | ALDH1A1 (0.39) | ALDH1A1MAPTCYP3A4ALOX15APP | |
| SCHEMBL9209368 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPTCYP3A4ALOX15APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802261-B1 | Enzymatic acylation of a retinol derivative | HOFFMANN LA ROCHE (CH) | 2001-08-08 | — | — | EP | claimed |
| JP-2007143561-A | APPLICATION OF ACYLATE | DSM IP ASSETS BV | 2007-06-14 | — | — | JP | disclosed |
| US-5902738-A | MAKING (11Z,13Z)-7,10-DIHYDRO-10-HYDROXY-RETINYL ACETATE AND OTHER ESTERS BY REACTING ACYLATING AGENT, LIPASE AND ORGANIC SOLVENT WITH (11Z,13Z)-7,10-DIHYDRO-10-HYDROXY RETINOL; FOR CHEMICAL INTERMEDIATES IN PRODUCTION OF VITAMIN A ACYLATES | ROCHE VITAMINS INC. (US) | 1999-05-11 | — | — | US | disclosed |