Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.33 |
| ▸ | GLB1 | P16278 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999773 | 0.92 | PLAT (0.37) | LMNATSHRKMT2AALDH1A1MAPT | |
| SCHEMBL5332950 | 0.80 | MEN1 (0.37) | LMNAKMT2AALDH1A1MAPTADRA1A | |
| SCHEMBL6658826 | 0.78 | TSHR (0.37) | LMNATSHRKMT2AALDH1A1MAPT | |
| SCHEMBL3125735 | 0.77 | PARP1 (0.33) | KMT2AALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL28251143 | 0.68 | SLC6A2 (0.34) | LMNAKMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL21689051 | 0.67 | KDM4E (0.43) | LMNATSHRKMT2AALDH1A1MAPT | |
| SCHEMBL819237 | 0.67 | TSHR (0.50) | LMNATSHRKMT2AALDH1A1MAPT | |
| SCHEMBL818859 | 0.66 | KDM4E (0.39) | LMNATSHRKMT2AALDH1A1MAPT | |
| SCHEMBL6219590 | 0.65 | TSHR (0.35) | LMNATSHRKMT2AALDH1A1MAPT | |
| SCHEMBL1126884 | 0.64 | KMT2A (0.44) | LMNATSHRKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |