Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | GLB1 | P16278 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL819237 | 0.67 | TSHR (0.50) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6658826 | 0.67 | TSHR (0.37) | TSHRKMT2AMEN1FUCA1GLB1 | |
| SCHEMBL7999773 | 0.67 | PLAT (0.37) | TSHRKMT2AMEN1FUCA1GLB1 | |
| SCHEMBL818859 | 0.66 | KDM4E (0.39) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5332473 | 0.65 | LMNA (0.35) | TSHRKMT2AMEN1FUCA1GLB1 | |
| SCHEMBL21689051 | 0.64 | KDM4E (0.43) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL12808756 | 0.61 | MEN1 (0.43) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL817678 | 0.61 | TSHR (0.43) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL19223084 | 0.60 | LMNA (0.42) | TSHRALDH1A1LMNAKDM4EGAA | |
| SCHEMBL14085314 | 0.60 | LMNA (0.39) | TSHRKMT2AMEN1PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585726-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063155-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |