Alcohol

Alcohol

SCHEMBL5332610

CCO.COc1cccc(CCO)c1

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.62
CHRM2 P08172 2/20 0.59
CHRM1 P11229 2/20 0.59
CHRM3 P20309 2/20 0.59
CYP4F2 P78329 1/20 0.57
CYP4A11 Q02928 1/20 0.57
SIGMAR1 Q99720 1/20 0.56
AOC3 Q16853 1/20 0.56
MTNR1A P48039 2/20 0.54
MTNR1B P49286 2/20 0.54
IDO1 P14902 2/20 0.53
AGXT P21549 2/20 0.53
HRH3 Q9Y5N1 1/20 0.53
ABCB1 P08183 1/20 0.53
HTR1A P08908 1/20 0.53
DRD2 P14416 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL43521 0.96 TAAR1 (0.67) TAAR1CHRM2CHRM1CHRM3CYP4F2
SCHEMBL81474 0.85 CHRM2 (0.63) TAAR1CHRM2CHRM1CHRM3SIGMAR1
SCHEMBL723511 0.84 TAAR1 (0.77) TAAR1CHRM2CHRM1CHRM3SIGMAR1
SCHEMBL30080050 0.84 TAAR1 (0.77) TAAR1CHRM2CHRM1CHRM3SIGMAR1
SCHEMBL23266720 0.84 CHRM2 (0.61) TAAR1CHRM2CHRM1CHRM3CYP4F2
SCHEMBL156300 0.82 TAAR1 (0.69) TAAR1CHRM2CHRM1CHRM3SIGMAR1
SCHEMBL15746740 0.82 HDAC1 (0.62) TAAR1CHRM2CHRM1CHRM3CYP4F2
SCHEMBL17274721 0.82 HDAC1 (0.62) TAAR1CHRM2CHRM1CHRM3CYP4F2
1,3-Dimethoxybenzene SCHEMBL27952551 0.82 MAPK1 (0.58) TAAR1MTNR1BIDO1AGXT
SCHEMBL8045887 0.81 CYP4F2 (0.67) TAAR1CHRM2CHRM1CHRM3CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773853-A1 MONOPHOSPHINE COMPOUNDS, TRANSITION METAL COMPLEXES THEREOF AND PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS USING THE COMPLEXES AS ASYMMETRIC CATALYSTS Sumitomo Chemical Company, Limited (JP) 2007-04-18 EP disclosed
WO-2005121157-A1 MONOPHOSPHINE COMPOUNDS, TRANSITION METAL COMPLEXES THEREOF AND PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS USING THE COMPLEXES AS ASYMMETRIC CATALYSTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-12-22 WO disclosed