Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5372075 | 0.99 | PDE5A (0.40) | PDE5AABCG2KDM1APDE4BPDE4D | |
| Hydrochloric Acid SCHEMBL5360340 | 0.89 | CHRNA7 (0.48) | — | |
| Hydrochloric Acid SCHEMBL5357538 | 0.88 | PDE5A (0.39) | PDE5AABCG2PDE4BPDE4DHDAC1 | |
| SCHEMBL5365432 | 0.87 | ABCG2 (0.50) | PDE5AABCG2PDE4BPDE4DHDAC1 | |
| Hydrochloric Acid SCHEMBL5328212 | 0.87 | ABCG2 (0.45) | PDE5AABCG2HDAC1HDAC6SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5328910 | 0.86 | PDE5A (0.38) | PDE5AABCG2HDAC1HDAC6NPC1 | |
| Hydrochloric Acid SCHEMBL5358447 | 0.86 | ABCG2 (0.49) | PDE5AABCG2PDE4BPDE4DHDAC1 | |
| SCHEMBL2857503 | 0.86 | PDE5A (0.38) | PDE5AHTR2CHDAC1HDAC6NPC1 | |
| Hydrochloric Acid SCHEMBL6103394 | 0.86 | ABCG2 (0.48) | PDE5AABCG2PDE4BPDE4DHDAC1 | |
| Hydrochloric Acid SCHEMBL5369756 | 0.86 | KMT2A (0.41) | HTTMEN1HPGDKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814885-A2 | NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006073610-A2 | NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |