Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365432 | 0.98 | ABCG2 (0.50) | ABCG2ABCB1ABCC1PDE5AHDAC1 | |
| Hydrochloric Acid SCHEMBL5358447 | 0.97 | ABCG2 (0.49) | ABCG2ABCB1ABCC1PDE5AHDAC1 | |
| Hydrochloric Acid SCHEMBL5363389 | 0.91 | ABCG2 (0.56) | ABCG2ABCB1ABCC1PDE5AHDAC1 | |
| Hydrochloric Acid SCHEMBL5328212 | 0.91 | ABCG2 (0.45) | ABCG2ABCB1ABCC1PDE5AHDAC1 | |
| Hydrochloric Acid SCHEMBL5324056 | 0.89 | BCL6 (0.44) | ABCG2PDE5AHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL5364779 | 0.87 | BRD4 (0.41) | ABCG2ABCB1ABCC1PDE5AHDAC1 | |
| SCHEMBL5333399 | 0.86 | PDE5A (0.41) | ABCG2PDE5AHDAC1HDAC6MTOR | |
| SCHEMBL6103594 | 0.85 | PDE5A (0.49) | ABCG2PDE5AHDAC1HDAC6PIK3CA | |
| Hydrochloric Acid SCHEMBL5372075 | 0.85 | PDE5A (0.40) | ABCG2PDE5AHDAC1HDAC6MTOR | |
| Hydrochloric Acid SCHEMBL5361577 | 0.84 | PDE5A (0.49) | ABCG2PDE5AHDAC1HDAC6PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128729-A1 | Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128729-A1 | Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them | HPSE, ENGASE, UGCG | ABCG2 3081/4885ABCB1 3506/4885ABCC1 3369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.