Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 8/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | PPM1A | P35813 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333744 | 1.00 | F2RL3 (0.37) | F2RL3ENPP2NR1H2NR1H3NR1I2 | |
| SCHEMBL5378191 | 0.95 | F2RL3 (0.38) | F2RL3ENPP2NR1H2NR1H3NR1I2 | |
| SCHEMBL5378187 | 0.95 | F2RL3 (0.38) | F2RL3ENPP2NR1H2NR1H3NR1I2 | |
| SCHEMBL5359999 | 0.92 | NPSR1 (0.38) | F2RL3ENPP2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5359991 | 0.92 | NPSR1 (0.38) | F2RL3ENPP2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5349786 | 0.91 | F2RL3 (0.42) | F2RL3ENPP2PPM1ASCN5ASCN9A | |
| SCHEMBL5349782 | 0.91 | F2RL3 (0.42) | F2RL3ENPP2PPM1ASCN5ASCN9A | |
| SCHEMBL5337864 | 0.88 | ENPP2 (0.38) | F2RL3ENPP2NR1H2NR1H3CYP2C9 | |
| SCHEMBL5337868 | 0.88 | ENPP2 (0.38) | F2RL3ENPP2NR1H2NR1H3CYP2C9 | |
| SCHEMBL5319914 | 0.86 | NR1H2 (0.39) | ENPP2NR1H2NR1H3NR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786424-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | The University of Kansas (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006023704-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | UNIVERSITY OF KANSAS (US) | 2006-03-02 | — | — | WO | claimed |