Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.60 |
| ▸ | CA1 | P00915 | 8/20 | 0.52 |
| ▸ | CA2 | P00918 | 8/20 | 0.52 |
| ▸ | CA9 | Q16790 | 7/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.49 |
| ▸ | CA4 | P22748 | 4/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465658 | 0.89 | PTGS2 (0.60) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL5316308 | 0.87 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL5337610 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL27448843 | 0.84 | CA2 (0.53) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL3690374 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL5309164 | 0.84 | CA1 (0.55) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL2466828 | 0.76 | CHRNA7 (0.66) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL5309196 | 0.76 | CHRNA7 (0.66) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL5312580 | 0.75 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL2463751 | 0.74 | PTGS2 (1.00) | PTGS2PTGS1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |