Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18856964 | 0.81 | HTR2A (0.59) | HTR2CHTR2ACDK4CCND1KMO | |
| SCHEMBL1612942 | 0.81 | HTR2C (0.55) | HTR2CHTR2AGLO1HTR7MTNR1A | |
| SCHEMBL21051475 | 0.81 | GLO1 (0.50) | HTR2CHTR2AGLO1ITGB2ICAM1 | |
| SCHEMBL3653449 | 0.81 | PRKCI (0.54) | HTR2CHTR2ACDK4CCND1GLO1 | |
| SCHEMBL27682298 | 0.80 | HTR2A (0.48) | HTR2CHTR2ACDK4CCND1KMO | |
| SCHEMBL14117445 | 0.79 | GLO1 (0.46) | HTR2CHTR2ACDK4CCND1GLO1 | |
| SCHEMBL18856955 | 0.79 | HTR2A (0.56) | HTR2CHTR2ACDK4CCND1KMO | |
| SCHEMBL13483885 | 0.78 | GLO1 (0.46) | HTR2CHTR2ACDK4CCND1GLO1 | |
| SCHEMBL31735936 | 0.78 | GLO1 (0.46) | HTR2CHTR2AGLO1ITGB2ICAM1 | |
| SCHEMBL8959527 | 0.78 | HTR2A (0.59) | HTR2CHTR2ACDK4CCND1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008514-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | GEORGETOWN UNIVERSITY (US) | 2007-01-18 | — | — | WO | disclosed |