Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.82 |
| ▸ | NPC1 | O15118 | 4/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | GAA | P10253 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29588162 | 0.90 | KDM4E (1.00) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL3639863 | 0.90 | KDM4E (1.00) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| Phosphine SCHEMBL15543212 | 0.89 | KDM4E (0.97) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL12325283 | 0.83 | KMT2A (1.00) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL3639865 | 0.77 | KDM4E (0.77) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL8027341 | 0.74 | RAB9A (0.60) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL16501702 | 0.74 | NPC1 (0.51) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL16509296 | 0.72 | KDM4E (0.50) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL16509324 | 0.72 | NPC1 (0.50) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL8337851 | 0.71 | POLB (1.00) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |