Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15966795 | 0.86 | ALDH1A1 (0.67) | KDM4EALDH1A1LMNARECQLGAA | |
| SCHEMBL1522936 | 0.85 | KDM4E (0.81) | KDM4EALDH1A1LMNAHIF1ARECQL | |
| SCHEMBL5124064 | 0.81 | ALDH1A1 (0.63) | KDM4EALDH1A1LMNARECQLGAA | |
| SCHEMBL5331127 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1LMNARECQLGAA | |
| SCHEMBL4754692 | 0.81 | ALDH1A1 (0.65) | KDM4EALDH1A1LMNARECQLGAA | |
| SCHEMBL5471793 | 0.81 | KDM4E (0.61) | KDM4EALDH1A1LMNAGAAMAPT | |
| SCHEMBL8245786 | 0.81 | HIF1A (0.75) | HIF1A | |
| SCHEMBL5529505 | 0.80 | ALDH1A1 (0.81) | KDM4EALDH1A1LMNARECQLGAA | |
| SCHEMBL14607234 | 0.78 | ALDH1A1 (0.62) | KDM4EALDH1A1LMNARECQLGAA | |
| SCHEMBL7832109 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1LMNARECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |