Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3733737 | 0.82 | CA1 (0.38) | — | |
| SCHEMBL2943387 | 0.77 | CA1 (0.54) | MAPK1KDM4ENR1H2GPR119JAK2 | |
| SCHEMBL3494790 | 0.77 | CA1 (0.54) | MAPK1KDM4ENR1H2GPR119JAK2 | |
| SCHEMBL17058 | 0.77 | CA1 (0.54) | MAPK1KDM4ENR1H2GPR119JAK2 | |
| SCHEMBL4972391 | 0.76 | GPR119 (0.47) | MAPK1NR1H2GPR119JAK2JAK1 | |
| SCHEMBL1462710 | 0.75 | NR1H2 (0.50) | MAPK1USP2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL336866 | 0.75 | NR1H2 (0.50) | MAPK1USP2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2799343 | 0.75 | NR1H2 (0.43) | MAPK1USP2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL18683 | 0.75 | NR1H2 (0.43) | MAPK1USP2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL334410 | 0.75 | NR1H2 (0.43) | MAPK1USP2SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836179-A1 | PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006074025-A1 | PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |