Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA4 | P22748 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334736 | 0.82 | MAPK1 (0.39) | — | |
| SCHEMBL5337404 | 0.76 | FAAH (0.44) | — | |
| SCHEMBL3495230 | 0.73 | CA1 (0.62) | CA1CA2CA4CA9PARP1 | |
| SCHEMBL4749948 | 0.73 | CA1 (0.62) | CA1CA2CA4CA9PARP1 | |
| SCHEMBL5719329 | 0.73 | CA1 (0.62) | CA1CA2CA4CA9PARP1 | |
| SCHEMBL3492392 | 0.71 | CA1 (0.51) | CA1CA2CA4CA9PARP1 | |
| SCHEMBL15005734 | 0.70 | REN (0.42) | CA1CA2CA4CA9PARP1 | |
| SCHEMBL2011996 | 0.70 | REN (0.42) | CA1CA2CA4CA9PARP1 | |
| SCHEMBL2418102 | 0.70 | REN (0.42) | CA1CA2CA4CA9PARP1 | |
| SCHEMBL4750177 | 0.69 | EPHX2 (0.43) | CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164493-A2 | HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | Janssen Pharmaceutica, N.V. (BE) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008153752-A2 | HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-18 | — | — | WO | disclosed |