Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HRAS | P01112 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12934351 | 0.97 | NAMPT (0.52) | NAMPTKDM4EPOLBMAPTP2RY12 | |
| SCHEMBL24630353 | 0.91 | NAMPT (0.43) | NAMPTKDM4EPOLBMAPTP2RY12 | |
| SCHEMBL6433630 | 0.89 | NAMPT (0.45) | NAMPTKDM4EPOLBMAPTP2RY12 | |
| SCHEMBL20485621 | 0.87 | NAMPT (0.52) | NAMPTKDM4EPOLBMAPTP2RY12 | |
| SCHEMBL12256120 | 0.86 | NAMPT (0.51) | NAMPTKDM4EPOLBMAPTP2RY12 | |
| SCHEMBL12256158 | 0.86 | NAMPT (0.53) | NAMPTKDM4EPOLBMAPTGRM1 | |
| SCHEMBL14072164 | 0.85 | P2RY12 (0.51) | NAMPTKDM4EPOLBMAPTP2RY12 | |
| SCHEMBL2072460 | 0.84 | NAMPT (0.54) | NAMPTKDM4EPOLBMAPTGRM1 | |
| SCHEMBL13682849 | 0.84 | NAMPT (0.52) | NAMPTKDM4EPOLBMAPTP2RY12 | |
| SCHEMBL12256163 | 0.84 | NAMPT (0.49) | NAMPTKDM4EPOLBMAPTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350145-B1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | UNIV TEXAS (US) | 2020-09-16 | — | — | EP | disclosed |
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-07-23 | — | — | US | disclosed |
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180251454-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-09-06 | — | — | US | disclosed |
| WO-2007045096-A1 | OLIGOHETEROAROMATIC LUMINISCENT ASSEMBLIES AS HIGH-AFFINITY DNA SEQUENCE-DIRECTED LIGANDS | UNIVERSITY OF SASKATCHEWAN (CA) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | TOP2B, TOP2A, TOP1 | NAMPT 3361/4885KDM4E 4024/4885POLB 9/4885 |
| US-20180251454-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | TOP2B, TOP2A, TOP1 | NAMPT 3361/4885KDM4E 4024/4885POLB 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.