Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374567 | 0.79 | SLC6A2 (0.43) | HDAC8RECQLRAB9AGALR3NR2F2 | |
| SCHEMBL20181741 | 0.74 | ASAH1 (0.42) | RECQLKMOPDE10ASMN1; SMN2LMNA | |
| SCHEMBL3862440 | 0.71 | RECQL (0.42) | HDAC8RECQLRAB9AKMOPDE10A | |
| SCHEMBL21591511 | 0.70 | RECQL (0.41) | HDAC8RECQLRAB9AKMOPDE10A | |
| SCHEMBL1135534 | 0.70 | RECQL (0.77) | RECQLRAB9AGALR3NR2F2KMO | |
| SCHEMBL30376517 | 0.69 | ASAH1 (0.42) | RECQLKMOPDE10ASMN1; SMN2LMNA | |
| SCHEMBL22810558 | 0.68 | ASAH1 (0.44) | RECQLSLC6A2 | |
| SCHEMBL878425 | 0.67 | RECQL (0.43) | RECQLRAB9AKMOPDE10ASMN1; SMN2 | |
| SCHEMBL29350890 | 0.67 | RECQL (0.43) | RECQLRAB9AKMOPDE10ASMN1; SMN2 | |
| SCHEMBL4785130 | 0.67 | ADRB2 (0.37) | HDAC8RECQLRAB9AALOX5APKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |