Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264585 | 0.85 | PRMT5 (0.38) | KDM4EALOX12MAPTTDP1ALDH1A1 | |
| Water SCHEMBL5259730 | 0.84 | PRMT5 (0.37) | KDM4EALOX12MAPTTDP1ALDH1A1 | |
| SCHEMBL5505830 | 0.78 | PRMT5 (0.38) | KDM4EALOX12MAPTTDP1ALDH1A1 | |
| SCHEMBL5350911 | 0.76 | HTT (0.36) | KDM4EALOX12MAPTTDP1ALDH1A1 | |
| SCHEMBL311313 | 0.73 | MMP2 (0.38) | KDM4EALOX12MAPTTDP1ALDH1A1 | |
| SCHEMBL5516518 | 0.70 | TP53 (0.36) | KDM4EALDH1A1NPSR1PRMT5TLR8 | |
| SCHEMBL311681 | 0.70 | PRMT5 (0.42) | KDM4EMAPTTDP1ALDH1A1LMNA | |
| SCHEMBL30413516 | 0.70 | PRMT5 (0.42) | KDM4EMAPTTDP1ALDH1A1LMNA | |
| SCHEMBL5375816 | 0.69 | TLR7 (0.44) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 | |
| Water SCHEMBL5343392 | 0.69 | TLR7 (0.43) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833833-A2 | POLYMORPHS OF 1-(2-METHYLPROPYL)-1H-IMIDAZO 4,5-C 1,5 NAPHTHYRIDIN-4-AMINE ETHANESULFONATE | Takeda Pharmaceutical Company Limited (JP) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071862-A2 | POLYMORPHS OF 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE ETHANESULFONATE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-07-06 | — | — | WO | disclosed |