SCHEMBL5336476

SCHEMBL5336476

O=C(O)CCSC1c2cc(C=Cc3ccc4cc(F)c(Cl)cc4n3)ccc2C=Cc2c(F)cccc21

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYSLTR1 Q9Y271 4/20 0.42
CYSLTR2 Q9NS75 3/20 0.42
ABCC1 P33527 2/20 0.39
MEN1 O00255 1/20 0.39
ABCC3 O15438 1/20 0.39
ABCC4 O15439 1/20 0.39
ABCC5 O15440 1/20 0.39
SLCO2B1 O94956 1/20 0.39
ABCB11 O95342 1/20 0.39
KMT2A Q03164 1/20 0.39
ABCC2 Q92887 1/20 0.39
SLCO1B3 Q9NPD5 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.39
SLCO1B1 Q9Y6L6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5336474 1.00 CYSLTR1 (0.42) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5335282 0.96 CYSLTR1 (0.42) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5335276 0.96 CYSLTR1 (0.42) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5337873 0.93 CYSLTR1 (0.42) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5337869 0.93 CYSLTR1 (0.42) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5338653 0.93 CYSLTR1 (0.40) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5338648 0.93 CYSLTR1 (0.40) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5339118 0.92 CYSLTR1 (0.45) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5339124 0.92 CYSLTR1 (0.45) CYSLTR1CYSLTR2ABCC1MEN1ABCC3
SCHEMBL5345548 0.90 CYSLTR1 (0.43) CYSLTR1CYSLTR2ABCC1MEN1ABCC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7309718-B2 Dibenzocycloheptene compound UBE INDUSTRIES, LTD. (JP) 2007-12-18 US claimed
US-20040180884-A1 Dibenzocycloheptene compound UBE INDUSTRIES, LTD. (JP) 2004-09-16 US claimed
EP-1408033-A1 DIBENZOCYCLOHEPTENE COMPOUND Ube Industries, Ltd. (JP) 2004-04-14 EP claimed
US-7309718-B2 Dibenzocycloheptene compound UBE INDUSTRIES, LTD. (JP) 2007-12-18 US disclosed
US-20040180884-A1 Dibenzocycloheptene compound UBE INDUSTRIES, LTD. (JP) 2004-09-16 US disclosed
EP-1408033-A1 DIBENZOCYCLOHEPTENE COMPOUND Ube Industries, Ltd. (JP) 2004-04-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040180884-A1 Dibenzocycloheptene compound LTB4R2, LTA4H, LTC4S CYSLTR1 6/4885CYSLTR2 5/4885ABCC1 1969/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.