Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 4/20 | 0.51 |
| ▸ | CASP7 | P55210 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5476494 | 0.84 | FFAR3 (0.54) | KDM4EHSD17B10GAATSHRGLA | |
| SCHEMBL3323801 | 0.83 | ALDH1A1 (0.57) | KDM4EHSD17B10GAATSHRGLA | |
| SCHEMBL3325469 | 0.82 | KDM4E (0.50) | KDM4EHSD17B10GAATSHRGLA | |
| SCHEMBL3325585 | 0.80 | KDM4E (0.53) | KDM4EHSD17B10GAATSHRGLA | |
| SCHEMBL12932132 | 0.80 | KDM4E (0.57) | KDM4EHSD17B10GAATSHRGLA | |
| SCHEMBL5317053 | 0.79 | ALDH1A1 (0.75) | KDM4EHSD17B10GAATSHRALDH1A1 | |
| SCHEMBL3324425 | 0.79 | ALDH1A1 (0.55) | KDM4EHSD17B10GAAGLAALDH1A1 | |
| SCHEMBL3324836 | 0.79 | ALDH1A1 (0.61) | KDM4EHSD17B10GAATSHRGLA | |
| SCHEMBL5332348 | 0.78 | KDM4E (0.51) | KDM4EHSD17B10GAAGLAALDH1A1 | |
| SCHEMBL3329937 | 0.78 | ALDH1A1 (0.51) | KDM4EHSD17B10GAATSHRGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245147-A1 | INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-09-27 | — | — | US | claimed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245147-A1 | INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH | HSPA5, HSP90B1, ATP2A1 | KDM4E 3850/4885HSD17B10 2678/4885GAA 239/4885 |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | KDM4E 4033/4885HSD17B10 3999/4885GAA 3421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.