Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799259 | 0.89 | GSTP1 (0.44) | KMT2AMEN1TSHRBRD4MAPT | |
| SCHEMBL819891 | 0.79 | TSHR (0.45) | KMT2AMEN1TSHRCA12CA1 | |
| SCHEMBL8569125 | 0.79 | PTPN1 (0.41) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL43932 | 0.78 | — | — | |
| SCHEMBL1779388 | 0.76 | ALDH1A1 (0.39) | KMT2AMEN1TSHRCA12CA1 | |
| SCHEMBL15957919 | 0.75 | PTPN1 (0.52) | KMT2AMEN1TSHRMAPTLMNA | |
| SCHEMBL31196992 | 0.74 | TSHR (0.48) | KMT2AMEN1TSHRCA12CA1 | |
| SCHEMBL13159212 | 0.74 | ALDH1A1 (0.52) | KMT2AMEN1TSHRCA12CA1 | |
| SCHEMBL6227521 | 0.73 | KMT2A (0.38) | KMT2AMEN1TSHRCA12CA1 | |
| SCHEMBL818456 | 0.72 | CA12 (0.44) | KMT2AMEN1TSHRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288650-B2 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2007-10-30 | — | — | US | disclosed |
| US-7074793-B2 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20060128780-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2006-06-15 | — | — | US | disclosed |
| US-6841567-B1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2005-01-11 | — | — | US | disclosed |
| US-20040186157-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2004-09-23 | — | — | US | disclosed |
| EP-1165562-A1 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | Cephalon, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000047583-A9 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | CEPHALON INC (US) | 2001-09-20 | — | — | WO | disclosed |
| WO-2000047583-A1 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | CEPHALON, INC. (US) | 2000-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186157-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | PIN1, PAICS, QPCT | KMT2A 3858/4885MEN1 3793/4885TSHR 4078/4885 |
| US-20060128780-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | PIN1, PAICS, QPCT | KMT2A 3858/4885MEN1 3793/4885TSHR 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.