Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.49 |
| ▸ | GRM5 | P41594 | 8/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344399 | 0.84 | CDK5 (0.63) | CDK5CDK5R1WNT3ADYRK1A | |
| SCHEMBL14558870 | 0.78 | CDK5 (0.54) | CDK5CDK5R1DYRK1A | |
| SCHEMBL5661859 | 0.78 | GRM1 (0.52) | GRM1GRM5NAMPTPDK4DGAT2 | |
| SCHEMBL14558911 | 0.78 | CDK5 (0.52) | CDK5CDK5R1GPR119DYRK1A | |
| SCHEMBL30308912 | 0.77 | GRM1 (0.64) | GRM1GRM5GPR119NAMPTPDK4 | |
| SCHEMBL23164876 | 0.77 | GPR119 (0.55) | GRM1GRM5GPR119NAMPTPDK4 | |
| SCHEMBL5341555 | 0.76 | CDK5 (0.50) | CDK5CDK5R1GPR119NAMPTWNT3A | |
| SCHEMBL1863518 | 0.76 | GRM1 (0.67) | GRM1GRM5GPR119NAMPTPDK4 | |
| SCHEMBL14558453 | 0.75 | CDK5 (0.49) | CDK5CDK5R1GPR119NAMPTDYRK1A | |
| SCHEMBL5344163 | 0.75 | CDK5 (0.55) | CDK5CDK5R1WNT3ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |