Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.63 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL555594 | 1.00 | REN (0.63) | RENKCNH2CYP3A4RORCALK | |
| SCHEMBL3719090 | 0.90 | REN (0.68) | RENKCNH2CYP3A4 | |
| SCHEMBL555742 | 0.89 | REN (0.62) | RENKCNH2CYP3A4RORCALK | |
| SCHEMBL555657 | 0.89 | REN (0.62) | RENKCNH2CYP3A4RORCALK | |
| SCHEMBL555815 | 0.89 | REN (0.61) | RENKCNH2CYP3A4RORCALK | |
| SCHEMBL556767 | 0.88 | REN (0.48) | RENKCNH2CYP3A4RORCALK | |
| SCHEMBL557228 | 0.88 | REN (0.53) | RENKCNH2CYP3A4RORCALK | |
| SCHEMBL557036 | 0.87 | REN (0.60) | RENKCNH2CYP3A4RORC | |
| SCHEMBL556026 | 0.86 | REN (0.56) | RENKCNH2CYP3A4RORCALK | |
| SCHEMBL556815 | 0.86 | REN (0.52) | RENKCNH2CYP3A4RORCALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |