Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870792 | 0.86 | PTGS1 (0.59) | EGLN1APPMAP3K5CLK1DYRK1A | |
| Hydrochloric Acid SCHEMBL1422913 | 0.84 | PTGS1 (0.57) | EGLN1APPMAP3K5CLK1DYRK1A | |
| SCHEMBL16104299 | 0.84 | CLK1 (0.55) | EGLN1APPMAP3K5CLK1DYRK1A | |
| SCHEMBL8176307 | 0.83 | APP (0.48) | EGLN1APPMAP3K5CLK1DYRK1A | |
| SCHEMBL13791874 | 0.79 | KDM4E (0.51) | PTGS1PTGS2METTL3HRH4HRH3 | |
| Hydrochloric Acid SCHEMBL3885254 | 0.78 | KDM4E (0.50) | PTGS1PTGS2METTL3HRH4HRH3 | |
| SCHEMBL2086460 | 0.78 | PTGS1 (0.50) | EGLN1MAP3K5PTGS1PTGS2METTL3 | |
| SCHEMBL3365512 | 0.77 | NPC1 (0.68) | EGLN1MAP3K5PTGS1PTGS2METTL3 | |
| SCHEMBL4098270 | 0.76 | KDM4E (0.64) | EGLN1NPC1RAB9A | |
| SCHEMBL21001625 | 0.76 | EGLN1 (0.67) | EGLN1APPCLK1DYRK1APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238691-B2 | Piperidine derivatives and their use as modulators of chemokine (especially CCR3) activity | ASTRAZENECA AB (SE) | 2007-07-03 | — | — | US | disclosed |
| EP-1430050-B1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE (ESPECIALLY CCR3) ACTIVITY | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | EP | disclosed |
| US-20040242577-A1 | Piperdine derivatives and their use as modulators of chemokine (especially ccr3) activity | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | disclosed |
| EP-1430050-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE (ESPECIALLY CCR3) ACTIVITY | AstraZeneca AB (SE) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003024962-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE (ESPECIALLY CCR3) ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242577-A1 | Piperdine derivatives and their use as modulators of chemokine (especially ccr3) activity | CCR3, CCR1, CCR2 | EGLN1 903/4885APP 2973/4885MAP3K5 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.