Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870792 | 0.86 | PTGS1 (0.59) | APPEGLN1MAP3K5CLK1DYRK1A | |
| SCHEMBL16104299 | 0.84 | CLK1 (0.55) | APPEGLN1MAP3K5CLK1DYRK1A | |
| Hydrochloric Acid SCHEMBL1422913 | 0.84 | PTGS1 (0.57) | APPEGLN1MAP3K5CLK1DYRK1A | |
| SCHEMBL5338541 | 0.83 | EGLN1 (0.47) | APPEGLN1MAP3K5CLK1DYRK1A | |
| SCHEMBL16376280 | 0.82 | RAB9A (0.50) | APPEGLN1MAP3K5PTGS1PTGS2 | |
| SCHEMBL15223780 | 0.81 | HRH4 (0.41) | EGLN1MAP3K5PTGS1PTGS2HRH4 | |
| SCHEMBL4098270 | 0.80 | KDM4E (0.64) | EGLN1KDM4EPOLB | |
| SCHEMBL20646875 | 0.79 | HRH4 (0.61) | APPEGLN1MAP3K5CLK1DYRK1A | |
| SCHEMBL18883283 | 0.79 | HRH4 (0.40) | APPEGLN1PTGS1PTGS2HRH4 | |
| SCHEMBL1500263 | 0.79 | PIK3CG (0.51) | APPEGLN1MAP3K5CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |