Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557571 | 0.78 | REN (0.41) | RENKCNH2CYP3A4 | |
| SCHEMBL10202569 | 0.76 | REN (0.76) | RENKCNH2CYP3A4 | |
| SCHEMBL534057 | 0.72 | REN (0.58) | RENKCNH2CYP3A4 | |
| SCHEMBL556618 | 0.71 | REN (0.75) | RENKCNH2CYP3A4 | |
| SCHEMBL535511 | 0.71 | REN (0.66) | RENKCNH2CYP3A4 | |
| SCHEMBL556870 | 0.70 | REN (0.75) | RENKCNH2CYP3A4 | |
| SCHEMBL535443 | 0.68 | REN (0.41) | RENKCNH2CYP3A4 | |
| SCHEMBL534449 | 0.68 | REN (0.66) | RENKCNH2CYP3A4 | |
| SCHEMBL534916 | 0.67 | REN (0.54) | RENKCNH2CYP3A4 | |
| SCHEMBL10202578 | 0.67 | REN (1.00) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |