Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.49 |
| ▸ | WEE1 | P30291 | 9/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | GLI1 | P08151 | 2/20 | 0.38 |
| ▸ | GLI2 | P10070 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345854 | 0.91 | WEE1 (0.49) | CHEK1WEE1CDK4 | |
| SCHEMBL5337935 | 0.90 | PARP1 (0.41) | CHEK1WEE1ROCK2GLI1GLI2 | |
| SCHEMBL5342513 | 0.77 | ABCG2 (0.47) | CHEK1WEE1ROCK2CDK4PRKACA | |
| SCHEMBL8498825 | 0.74 | CHEK1 (0.79) | CHEK1ROCK2GLI1GLI2CDK4 | |
| SCHEMBL5346736 | 0.73 | ABCG2 (0.38) | ROCK2CDK4PRKACAPRKACGPRKACB | |
| SCHEMBL5338184 | 0.70 | MAPT (0.34) | ROCK2KDM4EALDH1A1GLAGAA | |
| SCHEMBL5337778 | 0.67 | MAOB (0.40) | — | |
| SCHEMBL27648910 | 0.62 | IMPDH2 (0.67) | CHEK1WEE1ROCK2GLI1GLI2 | |
| SCHEMBL2714037 | 0.61 | MAOB (0.54) | KDM4EALDH1A1GAAHPGD | |
| SCHEMBL28849158 | 0.61 | IMPDH2 (0.74) | CHEK1WEE1ROCK2GLI1GLI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202255-B2 | Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-04-10 | — | — | US | disclosed |
| EP-1587810-B1 | NOVEL SUBSTITUTED 1,4|BENZODIOXINO 2,3-E|ISOINDOLE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2006-11-08 | — | — | EP | disclosed |
| US-20060040930-A1 | Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040930-A1 | Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | CYP11B2, CYP2F1, CYP3A43 | CHEK1 4285/4885WEE1 2710/4885ROCK2 2850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.