Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17560512 | 0.88 | ABCC9 (0.47) | PTPN11CYP17A1MAPKAPK2ABCC9KCNJ11 | |
| SCHEMBL17560513 | 0.88 | ABCC9 (0.47) | PTPN11CYP17A1MAPKAPK2ABCC9KCNJ11 | |
| SCHEMBL10092627 | 0.87 | CYP17A1 (0.48) | PTPN11CYP17A1PSMB8NR1H4PTPN2 | |
| SCHEMBL14155353 | 0.87 | CYP17A1 (0.48) | PTPN11CYP17A1PSMB8NR1H4PTPN2 | |
| SCHEMBL17902832 | 0.84 | MIF (0.45) | PTPN11CYP17A1PSMB8NR1H4MAPKAPK2 | |
| SCHEMBL17894453 | 0.84 | MIF (0.45) | PTPN11CYP17A1PSMB8NR1H4MAPKAPK2 | |
| SCHEMBL13293398 | 0.84 | CYP17A1 (0.43) | PTPN11CYP17A1PSMB8NR1H4PTPN2 | |
| SCHEMBL3777965 | 0.84 | CYP17A1 (0.40) | PTPN11CYP17A1PSMB8NR1H4 | |
| SCHEMBL13062960 | 0.84 | CYP17A1 (0.40) | PTPN11CYP17A1PSMB8NR1H4 | |
| SCHEMBL3777963 | 0.84 | CYP17A1 (0.40) | PTPN11CYP17A1PSMB8NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824468-A2 | GLYCOGEN SYNTHASE KINASE-3 INHIBITORS | Tel Aviv University Future Technology Development L.P. (IL) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006054298-A2 | GLYCOGEN SYNTHASE KINASE-3 INHIBITORS | TEL AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P. (IL) | 2006-05-26 | — | — | WO | disclosed |