Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6025193 | 0.79 | CRHR1 (0.42) | CRHR1HRH4 | |
| SCHEMBL4702271 | 0.79 | CRHR1 (0.39) | CRHR1 | |
| Hydrochloric Acid SCHEMBL6185923 | 0.74 | CRHR1 (0.43) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4703706 | 0.73 | MEN1 (0.40) | CRHR1 | |
| SCHEMBL3364082 | 0.72 | CRHR1 (0.45) | CRHR1MAPTHRH4 | |
| SCHEMBL3362302 | 0.72 | CRHR1 (0.41) | CRHR1HRH4 | |
| Hydrochloric Acid SCHEMBL3365007 | 0.71 | CRHR1 (0.44) | CRHR1MAPTHRH4 | |
| SCHEMBL4702330 | 0.71 | CRHR1 (0.41) | CRHR1MAPT | |
| SCHEMBL4698855 | 0.71 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL3366236 | 0.70 | CRHR1 (0.44) | CRHR1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214699-B2 | Indazole derivatives as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2007-05-08 | — | — | US | disclosed |