Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 13/20 | 0.51 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.45 |
| ▸ | BRAF | P15056 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | IL18 | Q14116 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317859 | 0.87 | KDR (0.56) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5319488 | 0.83 | MAP4K4 (0.46) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5318118 | 0.82 | KDR (0.54) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL20239135 | 0.79 | ACACB (0.45) | KDRMAP2K7POLBMAPTKMT2A | |
| SCHEMBL5343714 | 0.76 | KDR (0.49) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5316445 | 0.75 | KDR (0.48) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL18362139 | 0.75 | MEN1 (0.42) | KDRKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL5317905 | 0.75 | P2RX3 (0.45) | KDRTNNI3KMAPK14BRAFKDM4E | |
| SCHEMBL5337979 | 0.74 | KDR (0.46) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL18362098 | 0.73 | L3MBTL1 (0.58) | KDRMEN1LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076473-A2 | SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | BRAF, ARAF, RAF1 | KDR 555/4885TNNI3K 112/4885MAP2K7 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.