Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557684 | 0.85 | REN (0.61) | RENKCNH2CYP3A4OPRL1CHRM3 | |
| SCHEMBL533938 | 0.80 | REN (0.42) | RENKCNH2CYP3A4CHRM3 | |
| SCHEMBL556463 | 0.73 | REN (0.58) | RENKCNH2CYP3A4KMT2AMTNR1A | |
| SCHEMBL10202582 | 0.72 | REN (0.82) | RENKCNH2CYP3A4 | |
| SCHEMBL535144 | 0.69 | REN (0.74) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL556088 | 0.69 | REN (0.41) | RENKCNH2CYP3A4CHRM3 | |
| SCHEMBL556870 | 0.69 | REN (0.75) | RENKCNH2CYP3A4CHRM3SMN1; SMN2 | |
| SCHEMBL555467 | 0.68 | REN (0.61) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL534448 | 0.67 | REN (0.48) | RENKCNH2CYP3A4L3MBTL1 | |
| SCHEMBL556618 | 0.67 | REN (0.75) | RENKCNH2CYP3A4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |