Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 3/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ARF6 | P62330 | 1/20 | 0.30 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534056 | 0.84 | REN (0.39) | RENKCNH2CYP3A4BRD9DPP4 | |
| SCHEMBL534057 | 0.83 | REN (0.58) | RENKCNH2CYP3A4ALDH2DPP4 | |
| SCHEMBL533994 | 0.80 | REN (0.46) | RENKCNH2CYP3A4CHRM3 | |
| SCHEMBL556088 | 0.76 | REN (0.41) | RENKCNH2CYP3A4DPP4DPP7 | |
| SCHEMBL535442 | 0.73 | REN (0.41) | RENKCNH2CYP3A4CHRM3PTGER1 | |
| SCHEMBL535144 | 0.73 | REN (0.74) | RENKCNH2CYP3A4ALDH2 | |
| SCHEMBL535443 | 0.73 | REN (0.41) | RENKCNH2CYP3A4CHRM3PTGER1 | |
| SCHEMBL534916 | 0.72 | REN (0.54) | RENKCNH2CYP3A4 | |
| SCHEMBL556870 | 0.72 | REN (0.75) | RENKCNH2CYP3A4DPP4CHRM3 | |
| SCHEMBL534448 | 0.71 | REN (0.48) | RENKCNH2CYP3A4PTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |