Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.77 |
| ▸ | MEN1 | O00255 | 6/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | RAB9A | P51151 | 3/20 | 0.77 |
| ▸ | TP53 | P04637 | 5/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246115 | 0.87 | MAPT (1.00) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL2245625 | 0.83 | MAPT (0.76) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL13855422 | 0.83 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL2248103 | 0.82 | MAPT (0.74) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL13857585 | 0.81 | MAPT (0.73) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL29401486 | 0.81 | MAPT (0.69) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL12963179 | 0.81 | MAPT (0.73) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL16602315 | 0.81 | MAPT (0.72) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL28452457 | 0.81 | MAPT (0.69) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL12980262 | 0.79 | MAPT (0.69) | MAPTMEN1KMT2AKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |