Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534006 | 0.91 | PTGDR2 (0.50) | PTGDR2FAAHDHFRMAPTMMP9 | |
| SCHEMBL533970 | 0.86 | PTGDR2 (0.68) | PTGDR2FAAHALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL534884 | 0.86 | PTGDR2 (0.59) | PTGDR2FAAHDHFRMAPTALDH1A1 | |
| SCHEMBL534795 | 0.84 | PTGDR2 (0.51) | PTGDR2CCNE2CCNE1CDK2 | |
| SCHEMBL534081 | 0.82 | PTGDR2 (0.49) | PTGDR2 | |
| SCHEMBL534921 | 0.81 | PTGDR2 (0.49) | PTGDR2 | |
| SCHEMBL2572569 | 0.80 | PTGDR2 (0.56) | PTGDR2CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3772517 | 0.76 | PTGDR2 (0.66) | PTGDR2DHFRMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL534119 | 0.76 | PTGDR2 (0.55) | PTGDR2DHFRP2RX3 | |
| SCHEMBL534118 | 0.76 | PTGDR2 (0.55) | PTGDR2DHFRP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129661-B1 | QUINOLINE DERIVATIVES AS CRTH2 RECEPTOR LIGANDS | PULMAGEN THERAPEUTICS ASTHMA LTD (GB) | 2012-02-08 | — | — | EP | claimed |