Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31648307 | 0.84 | ALDH1A1 (0.71) | ALDH1A1KMT2AKDM4EAPPGAA | |
| SCHEMBL2491556 | 0.84 | ALDH1A1 (0.71) | ALDH1A1KMT2AKDM4EAPPGAA | |
| SCHEMBL30659698 | 0.84 | ALDH1A1 (0.71) | ALDH1A1KMT2AKDM4EAPPGAA | |
| SCHEMBL4641797 | 0.83 | ALDH1A1 (0.62) | ALDH1A1KMT2AKDM4EAPPGAA | |
| SCHEMBL27893145 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KMT2AKDM4EAPPGAA | |
| SCHEMBL27673236 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KMT2AKDM4EAPPGAA | |
| Ammonia Solution, Strong SCHEMBL28264184 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KMT2AKDM4EAPPGAA | |
| SCHEMBL11524023 | 0.81 | L3MBTL1 (0.61) | ALDH1A1KMT2AKDM4EGAAMAPT | |
| SCHEMBL4644655 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KMT2AKDM4EAPPGAA | |
| SCHEMBL10603067 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KMT2AKDM4EAPPGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312334-B2 | Method of preparing inhibitors phosphodiesterase-4 | MERCK & CO. INC. (US) | 2007-12-25 | — | — | US | disclosed |
| CN-1326856-C | Method of preparing inhibitors of phosphodiesterase-4 | MERCK & CO INC (US) | 2007-07-18 | — | — | CN | disclosed |
| CN-1738818-A | Process for preparing phosphodiesterase-4 inhibitors | MERCK & CO INC (US) | 2006-02-22 | — | — | CN | disclosed |
| US-20060019981-A1 | Method of preparing inhibitors phosphodiesterase-4 | MERCK & CO., INC. | 2006-01-26 | — | — | US | disclosed |
| EP-1397359-B1 | 1-BIARYL-1,8-NAPTHYRIDIN-4-ONE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-08-31 | — | — | EP | disclosed |
| EP-1565466-A2 | METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4 | Merck & Co., Inc. (US) | 2005-08-24 | — | — | EP | disclosed |
| US-6909002-B2 | Method of preparing inhibitors of phosphodiesterase-4 | MERCK & CO., INC. (US) | 2005-06-21 | — | — | US | disclosed |
| WO-2004048377-A2 | METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4 | MERCK & CO., INC. (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20040102472-A1 | Method of preparing inhibitors of phosphodiesterase-4 | MERCK & CO., INC. | 2004-05-27 | — | — | US | disclosed |
| EP-1397359-A1 | 1-BIARYL-1,8-NAPTHYRIDIN-4-ONE PHOSPHODIESTERASE-4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-03-17 | — | — | EP | disclosed |
| US-6677351-B2 | USEFUL IN TREATMENT OF ASTHMA AND INFLAMMATION | MERCK FROSST CANADA & CO. (CA) | 2004-01-13 | — | — | US | disclosed |
| US-20030096829-A1 | 1-biaryl-1,8-naphthyridin-4-one phosphodiesterase-4 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2003-05-22 | — | — | US | disclosed |
| WO-2002094823-A1 | 1-BIARYL-1,8-NAPTHYRIDIN-4-ONE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102472-A1 | Method of preparing inhibitors of phosphodiesterase-4 | PDE4B, PDE4A, PDE5A | ALDH1A1 558/4885KMT2A 2291/4885KDM4E 467/4885 |
| US-20030096829-A1 | 1-biaryl-1,8-naphthyridin-4-one phosphodiesterase-4 inhibitors | PDE4A, PDE4B, PDE7A | ALDH1A1 314/4885KMT2A 2300/4885KDM4E 1159/4885 |
| US-20060019981-A1 | Method of preparing inhibitors phosphodiesterase-4 | PDE4A, PDE5A, PDE3A | ALDH1A1 572/4885KMT2A 2125/4885KDM4E 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.