Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 18/20 | 0.48 |
| ▸ | NOS1 | P29475 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560184 | 0.77 | NOS2 (0.53) | NOS2NOS1 | |
| SCHEMBL3569388 | 0.75 | NOS2 (0.60) | NOS2NOS1TSHR | |
| Hydrochloric Acid SCHEMBL3571851 | 0.74 | NOS2 (0.60) | NOS2NOS1TSHR | |
| SCHEMBL3562923 | 0.73 | NOS2 (0.58) | NOS2NOS1TSHR | |
| SCHEMBL5340887 | 0.73 | NOS2 (0.61) | NOS2NOS1 | |
| SCHEMBL3556108 | 0.71 | NOS1 (0.55) | NOS2NOS1KDM4ETSHRMAPK1 | |
| SCHEMBL3566595 | 0.70 | NOS2 (0.59) | NOS2NOS1KDM4ETSHRMAPK1 | |
| SCHEMBL3561935 | 0.69 | NOS2 (0.51) | NOS2NOS1 | |
| SCHEMBL5340900 | 0.67 | NOS2 (0.65) | NOS2NOS1 | |
| SCHEMBL4884982 | 0.67 | NOS2 (0.61) | NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062417-A1 | METHODS OF PREPARING 2-IMIDAZOL-1-YL-4-METHYL-6-PYRROLIDIN-2-YL-PYRIMIDINE AND 4-(1-ALKYLPYRROLIDIN-2-YL)-2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDINE DERIVATIVES | KALYPSYS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |