Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341992 | 0.72 | JAK2 (0.47) | CDC7DBF4JAK2CSNK2A1 | |
| SCHEMBL16793748 | 0.71 | BTK (0.63) | BTKAAK1 | |
| SCHEMBL15074549 | 0.69 | CDC7 (0.55) | CDC7DBF4JAK2ADORA3ADORA2A | |
| SCHEMBL14007210 | 0.67 | AKT3 (0.55) | L3MBTL1BTK | |
| SCHEMBL3336071 | 0.66 | HRH4 (0.60) | — | |
| SCHEMBL29631866 | 0.65 | KDM4A (0.43) | MAPKAPK2L3MBTL1KDM4A | |
| SCHEMBL19013326 | 0.65 | KDM4A (0.43) | MAPKAPK2L3MBTL1KDM4A | |
| SCHEMBL3778944 | 0.64 | HRH3 (0.59) | BRD4ADORA2A | |
| SCHEMBL509487 | 0.63 | KDM5B (0.53) | BRD4 | |
| SCHEMBL31627088 | 0.63 | NPSR1 (0.45) | BRD4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096334-A1 | PYRROLOPYRROLONES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2007-08-30 | — | — | WO | claimed |