Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.47 |
| ▸ | CDC7 | O00311 | 4/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5439588 | 0.89 | ADORA3 (0.38) | JAK2CDK5 | |
| SCHEMBL3704977 | 0.78 | JAK2 (0.51) | JAK2CDC7DBF4CDK1CDK2 | |
| SCHEMBL3703397 | 0.77 | JAK2 (0.55) | JAK2CDC7DBF4CDK1CDK2 | |
| Hydrochloric Acid SCHEMBL3703396 | 0.76 | JAK2 (0.54) | JAK2CDC7DBF4CDK1CDK2 | |
| SCHEMBL4191439 | 0.73 | JAK2 (0.71) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL4763445 | 0.73 | CDC7 (0.71) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL15231177 | 0.73 | PIM1 (0.55) | PIM1PIM3 | |
| SCHEMBL5341989 | 0.72 | CDC7 (0.39) | JAK2CDC7DBF4CSNK2A1 | |
| SCHEMBL4185870 | 0.72 | JAK2 (0.76) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL4190444 | 0.72 | CDC7 (0.53) | JAK2CDC7DBF4CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096334-A1 | PYRROLOPYRROLONES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2007-08-30 | — | — | WO | claimed |