Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5338130 | 0.88 | CDK5 (0.45) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5355037 | 0.86 | CDK5 (0.41) | CDK5CDK5R1DYRK1AROCK1ALDH1A1 | |
| SCHEMBL5345065 | 0.86 | CDK5 (0.41) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5342649 | 0.85 | CDK5 (0.52) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5354577 | 0.85 | CDK5 (0.53) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5342249 | 0.84 | CDK5 (0.43) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5345465 | 0.84 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5345480 | 0.83 | CDK5 (0.45) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5339061 | 0.83 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5342095 | 0.83 | CDK5 (0.43) | CDK5CDK5R1DYRK1AROCK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | CDK5 64/4885CDK5R1 359/4885IKBKE 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.