Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.36 |
| ▸ | CPT2 | P23786 | 2/20 | 0.36 |
| ▸ | CPT1A | P50416 | 2/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534339 | 0.79 | CD274 (0.39) | CD274HCRTR1HCRTR2PDCD1TMEM97 | |
| SCHEMBL5078499 | 0.72 | HSP90AA1 (0.56) | — | |
| SCHEMBL27223574 | 0.70 | BACE1 (0.40) | CPT2CPT1AFKBP1A | |
| SCHEMBL27223527 | 0.69 | EPHX1 (0.39) | CPT2CPT1AFKBP1A | |
| SCHEMBL17093004 | 0.68 | RIPK1 (0.51) | — | |
| SCHEMBL6310168 | 0.68 | HSP90AA1 (0.61) | — | |
| SCHEMBL535098 | 0.68 | RIPK1 (0.52) | NPC1RAB9A | |
| SCHEMBL16964986 | 0.67 | RIPK1 (0.48) | NPC1RAB9A | |
| SCHEMBL216202 | 0.67 | RIPK1 (0.62) | — | |
| SCHEMBL27574946 | 0.67 | RIPK1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |