Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.49 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311128 | 0.95 | RIPK1 (0.57) | RIPK1HSD11B1ADAM17SCD5SCD | |
| SCHEMBL216202 | 0.90 | RIPK1 (0.62) | RIPK1HSD11B1SCD5SCDHSP90AA1 | |
| SCHEMBL27574946 | 0.90 | RIPK1 (0.62) | RIPK1HSD11B1SCD5SCDHSP90AA1 | |
| SCHEMBL27574934 | 0.90 | RIPK1 (0.62) | RIPK1HSD11B1SCD5SCDHSP90AA1 | |
| Water SCHEMBL27700791 | 0.89 | RIPK1 (0.60) | RIPK1HSD11B1SCD5SCDHSP90AA1 | |
| SCHEMBL17558248 | 0.85 | RIPK1 (0.69) | RIPK1HSD11B1SCD5SCDHSP90AA1 | |
| SCHEMBL1847627 | 0.85 | RIPK1 (0.69) | RIPK1HSD11B1SCD5SCDHSP90AA1 | |
| SCHEMBL1853141 | 0.85 | RIPK1 (0.69) | RIPK1HSD11B1SCD5SCDHSP90AA1 | |
| SCHEMBL29892279 | 0.83 | CCNC (0.51) | RIPK1HSD11B1SCD5 | |
| SCHEMBL14920930 | 0.83 | HSD11B1 (0.54) | RIPK1HSD11B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |