Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 7/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | TERT | O14746 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | PPARD | Q03181 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344830 | 1.00 | FAAH (0.52) | FAAHCES1TERTPTPN1PPARG | |
| SCHEMBL6016882 | 0.92 | FAAH (0.44) | FAAHCES1CYP1A2HSD17B10KMT2A | |
| SCHEMBL10380718 | 0.84 | FAAH (0.48) | FAAHCES1CYP1A2HSD17B10KMT2A | |
| SCHEMBL11060939 | 0.81 | FAAH (0.57) | FAAHTERTPTPN1PPARGPPARD | |
| SCHEMBL9791850 | 0.81 | FAAH (0.57) | FAAHTERTPTPN1PPARGPPARD | |
| SCHEMBL1417477 | 0.80 | FAAH (0.58) | FAAHCES1TERTPTPN1PPARG | |
| Hydrochloric Acid SCHEMBL9575620 | 0.79 | FAAH (0.57) | FAAHTERTPTPN1PPARGPPARD | |
| Bromide SCHEMBL9575632 | 0.79 | FAAH (0.57) | FAAHTERTPTPN1PPARGPPARD | |
| SCHEMBL28857015 | 0.77 | FAAH (0.58) | FAAHCES1TERTPTPN1PPARG | |
| SCHEMBL26121847 | 0.77 | FAAH (0.56) | FAAHTERTPTPN1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102785-B1 | COMPOSITIONS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES | ARROWHEAD RES CORP (US) | 2013-02-13 | — | — | EP | disclosed |
| US-7208314-B2 | Compositions and methods for drug delivery using pH sensitive molecules | MIRUS BIO CORPORATION (US) | 2007-04-24 | — | — | US | disclosed |
| US-7138382-B2 | Compositions and methods for drug delivery using pH sensitive molecules | MIRUS BIO CORPORATION (US) | 2006-11-21 | — | — | US | disclosed |
| US-7098030-B2 | Polyampholytes for delivering polyions to a cell | MIRUS BIO CORPORATION (US) | 2006-08-29 | — | — | US | disclosed |
| US-7098032-B2 | Compositions and methods for drug delivery using pH sensitive molecules | MIRUS BIO CORPORATION (US) | 2006-08-29 | — | — | US | disclosed |
| EP-1102785-A4 | COMPOSITIONS AND METHODS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES | MIRUS CORP (US) | 2006-04-05 | — | — | EP | disclosed |
| EP-1620560-A1 | DELIVERY OF SIRNA TO CELLS USING POLYAMPHOLYTES | Mirus Corporation (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6919091-B2 | Compositions and methods for drug delivery using pH sensitive molecules | MIRUS CORPORATION (US) | 2005-07-19 | — | — | US | disclosed |
| US-20050123600-A1 | Compositions and methods for drug delivery using pH sensitive molecules | ROCHE MADISON INC. | 2005-06-09 | — | — | US | disclosed |
| US-20050037496-A1 | Polyampholytes for delivering polyions to a cell | Arrowhead Madison Inc. | 2005-02-17 | — | — | US | disclosed |
| WO-2004076674-A1 | DELIVERY OF SIRNA TO CELLS USING POLYAMPHOLYTES | MIRUS CORPORATION (US) | 2004-09-10 | — | — | WO | disclosed |
| US-20040162235-A1 | Delivery of siRNA to cells using polyampholytes | MILLIPORE CORPORATION | 2004-08-19 | — | — | US | disclosed |
| US-20040058446-A1 | Compositions and methods for drug delivery using pH sensitive molecules | Arrowhead Madison Inc. | 2004-03-25 | — | — | US | disclosed |
| US-20030199090-A1 | Compositions and methods for drug delivery using pH sensitive molecules | Arrowhead Pharmaceuticals, Inc. | 2003-10-23 | — | — | US | disclosed |
| US-6630351-B1 | Transfecting a cell by attaching a reversible labile membrane activity inhibitor to a melittin peptide; adding peptide to solution containing the nucleic acid; endocytosis | MIRUS CORPORATION | 2003-10-07 | — | — | US | disclosed |
| US-20030026841-A1 | Compositions and methods for drug delivery using pH sensitive molecules | Arrowhead Madison Inc. | 2003-02-06 | — | — | US | disclosed |
| EP-1102785-A1 | COMPOSITIONS AND METHODS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES | Mirus Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000075164-A1 | COMPOSITIONS AND METHODS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES | MIRUS CORPORATION (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058446-A1 | Compositions and methods for drug delivery using pH sensitive molecules | ABCC1, DNA2, ANXA6 | FAAH 1698/4885CES1 1083/4885TERT 1731/4885 |
| US-20030026841-A1 | Compositions and methods for drug delivery using pH sensitive molecules | POLI, POLN, POLRMT | FAAH 3223/4885CES1 3753/4885TERT 2717/4885 |
| US-20050123600-A1 | Compositions and methods for drug delivery using pH sensitive molecules | POLI, POLN, POLRMT | FAAH 3223/4885CES1 3753/4885TERT 2717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.