Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cimetidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 2/20 | 0.65 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ATP4A | P20648 | 1/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | ATP4B | P51164 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.65 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cimetidine SCHEMBL5999907 | 1.00 | SLC47A1 (0.65) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL534521 | 1.00 | SLC47A1 (0.65) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL10855579 | 1.00 | SLC47A1 (0.65) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL11156751 | 0.99 | SLC47A1 (0.64) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL11156749 | 0.99 | SLC47A1 (0.64) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL10338624 | 0.94 | SLC47A1 (0.69) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL11527651 | 0.93 | HRH2 (0.63) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL11527648 | 0.93 | HRH2 (0.63) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL11074155 | 0.90 | HRH2 (0.68) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL11073364 | 0.90 | SLC47A1 (0.55) | SLC47A1HRH2MEN1SLC22A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9272037-B2 | Method to treat premature ejaculation in humans | TRINITY LABORATORIES, INC. (US) | 2016-03-01 | — | — | US | claimed |
| US-20140296262-A1 | Method to Treat Premature Ejaculation in Humans | TRINITY LABORATORIES, INC. (US) | 2014-10-02 | — | — | US | claimed |
| US-20090215810-A1 | Method to Treat Premature Ejaculation in Humans | TRINITY LABORATORIES, INC. (US) | 2009-08-27 | — | — | US | claimed |
| US-20040235954-A1 | Method for treatment of premature ejaculation in humans | JEFFERSON BANK | 2004-11-25 | — | — | US | claimed |
| WO-2004043365-A2 | METHOD FOR TREATMENT OF PREMATURE EJACULATION IN HUMANS | AZAYA THERAPEUTICS, INC. (US) | 2004-05-27 | — | — | WO | claimed |
| EP-0367484-B1 | Carboxylic acid derivates | GLAXO GROUP LTD (GB) | 1994-02-16 | — | — | EP | claimed |
| EP-0279161-B1 | A process for the preparation of cimetidine | LEK TOVARNA FARMACEVTSKIH (SI) | 1994-01-05 | — | — | EP | claimed |
| EP-0571463-A1 | NOVEL CIMETIDINE POLYMORPH AND PROCESS FOR PREPARING SAME | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1993-12-01 | — | — | EP | claimed |
| WO-1992014713-A1 | NOVEL CIMETIDINE POLYMORPH AND PROCESS FOR PREPARING SAME | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1992-09-03 | — | — | WO | claimed |
| EP-0261818-B1 | PROCESS FOR PREPARATION OF GUANIDINE DERIVATIVE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1991-12-11 | — | — | EP | claimed |
| US-4973703-A | ACTIVATED CARBON IN WATER IN PRESENCE OR ORGANIC ACID | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-11-27 | — | — | US | claimed |
| US-4855439-A | Process for the preparation of cimetidine | LEK (YU) | 1989-08-08 | — | — | US | claimed |
| US-4808726-A | REACTING N-CYANO-N*-METHYL-N\"-(2-(BUTANE-2,3-DIONYL) THIOETHYL) GUANIDINE WITH AMMONIUM SALT OF A CARBOXYLIC ACID AND FORMALDEHYDE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-02-28 | — | — | US | claimed |
| EP-0261818-A1 | Process for preparation of guanidine derivative | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-30 | — | — | EP | claimed |
| EP-0120637-B1 | BENZOQUINOLIZINES | JOHN WYETH & BROTHER LIMITED (GB) | 1988-01-20 | — | — | EP | claimed |
| EP-0224612-A1 | Process for the preparation of N-cyano-N'-methyl-N''[2-(5-methylimidazol-4-ylmethylthio)-ethyl]-guanidine | HEUMANN PHARMA GMBH & CO (DE) | 1987-06-10 | — | — | EP | claimed |
| US-4537900-A | H2-RECEPTOR ANTAGONISTS, ANTIULCER AGENTS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-08-27 | — | — | US | claimed |
| EP-0046290-B1 | SYNERGISTIC COMBINATION OF (R,S)ALPHA-FLUOROMETHYLHISTIDINE AND CIMETIDINE AS AN ANTI-ULCER AGENT | MERCK & CO. INC. (US) | 1985-01-02 | — | — | EP | claimed |
| JP-56142269-A | — | — | None | — | — | JP | disclosed |
| US-4063023-A | Process for preparing 4-(hydroxymethyl)imidazole compounds | SK&F LAB CO. (US) | 1977-12-13 | — | — | US | disclosed |