Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cimetidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 2/20 | 0.65 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ATP4A | P20648 | 1/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | ATP4B | P51164 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.65 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cimetidine SCHEMBL534522 | 1.00 | SLC47A1 (0.65) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL5999907 | 1.00 | SLC47A1 (0.65) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL10855579 | 1.00 | SLC47A1 (0.65) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL11156751 | 0.99 | SLC47A1 (0.64) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL11156749 | 0.99 | SLC47A1 (0.64) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL10338624 | 0.94 | SLC47A1 (0.69) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL11527651 | 0.93 | HRH2 (0.63) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL11527648 | 0.93 | HRH2 (0.63) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL11074155 | 0.90 | HRH2 (0.68) | SLC47A1HRH2MEN1SLC22A2LMNA | |
| SCHEMBL11073364 | 0.90 | SLC47A1 (0.55) | SLC47A1HRH2MEN1SLC22A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367484-B1 | Carboxylic acid derivates | GLAXO GROUP LTD (GB) | 1994-02-16 | — | — | EP | claimed |
| EP-0571463-A1 | NOVEL CIMETIDINE POLYMORPH AND PROCESS FOR PREPARING SAME | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1993-12-01 | — | — | EP | claimed |
| WO-1992014713-A1 | NOVEL CIMETIDINE POLYMORPH AND PROCESS FOR PREPARING SAME | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1992-09-03 | — | — | WO | claimed |
| EP-0261818-B1 | PROCESS FOR PREPARATION OF GUANIDINE DERIVATIVE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1991-12-11 | — | — | EP | claimed |
| US-4973703-A | ACTIVATED CARBON IN WATER IN PRESENCE OR ORGANIC ACID | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-11-27 | — | — | US | claimed |
| EP-0261818-A1 | Process for preparation of guanidine derivative | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-30 | — | — | EP | claimed |
| JP-63060970-A | — | — | None | — | — | JP | disclosed |
| JP-63201171-A | — | — | None | — | — | JP | disclosed |
| JP-59007172-A | — | — | None | — | — | JP | disclosed |
| US-11213566-B2 | Oral care compositions and methods | LUBRIS LLC (US) | 2022-01-04 | — | — | US | disclosed |
| US-20190254939-A1 | Strip for the Delivery of an Oral Care Active and Methods for Applying Oral Care Actives | THE PROCTER & GAMBLE COMPANY | 2019-08-22 | — | — | US | disclosed |
| US-10285916-B2 | Strip for the delivery of an oral care active and methods for applying oral care actives | THE PROCTER & GAMBLE COMPANY (US) | 2019-05-14 | — | — | US | disclosed |
| US-10285915-B2 | Strip for the delivery of an oral care active and methods for applying oral care actives | THE PROCTER & GAMBLE COMPANY (US) | 2019-05-14 | — | — | US | disclosed |
| US-4171325-A | Chemical process | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-10-16 | — | — | US | disclosed |
| US-4171325-A | Chemical process | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-10-16 | — | — | US | disclosed |
| US-4163858-A | Process for preparing new imidazolemethylphosphonium salts | SK&F LAB CO. (US) | 1979-08-07 | — | — | US | disclosed |
| US-4139708-A | Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts | SK&F LAB CO. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4119781-A | Process for preparing 4-substituted imidazole compounds | SK&F LAB CO. (US) | 1978-10-10 | — | — | US | disclosed |
| US-4104472-A | Imidazolemethylphosphonium salts | SMITHKLINE CORPORATION (US) | 1978-08-01 | — | — | US | disclosed |
| US-4063023-A | Process for preparing 4-(hydroxymethyl)imidazole compounds | SK&F LAB CO. (US) | 1977-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190254939-A1 | Strip for the Delivery of an Oral Care Active and Methods for Applying Oral Care Actives | ACTN1, KRT18, CDH1 | HRH2 3640/4885SLC47A1 1745/4885MEN1 4585/4885 |
| US-10285916-B2 | Strip for the delivery of an oral care active and methods for applying oral care actives | ACTN1, KRT18, CDH1 | HRH2 3640/4885SLC47A1 1745/4885MEN1 4585/4885 |
| US-10285915-B2 | Strip for the delivery of an oral care active and methods for applying oral care actives | ACTN1, KRT18, CDH1 | HRH2 3640/4885SLC47A1 1745/4885MEN1 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.