Cimetidine

Cimetidine

SCHEMBL5999907

CN/C(=N\CCSCc1nc[nH]c1C)NC#N

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH2

The experimentally established mechanism targets of Cimetidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 known ✓ P25021 2/20 0.65
SLC47A1 Q96FL8 2/20 0.65
MEN1 O00255 1/20 0.65
SLC22A2 O15244 1/20 0.65
LMNA P02545 1/20 0.65
CYP1A2 P05177 1/20 0.65
GLA P06280 1/20 0.65
CYP3A4 P08684 1/20 0.65
CYP2D6 P10635 1/20 0.65
TSHR P16473 1/20 0.65
ATP4A P20648 1/20 0.65
APEX1 P27695 1/20 0.65
PDE4A P27815 1/20 0.65
CYP2C19 P33261 1/20 0.65
ADRA1A P35348 1/20 0.65
ATP4B P51164 1/20 0.65
KMT2A Q03164 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
SLC47A2 Q86VL8 1/20 0.65
SLC22A8 Q8TCC7 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cimetidine SCHEMBL534522 1.00 SLC47A1 (0.65) SLC47A1HRH2MEN1SLC22A2LMNA
Cimetidine SCHEMBL534521 1.00 SLC47A1 (0.65) SLC47A1HRH2MEN1SLC22A2LMNA
Cimetidine SCHEMBL10855579 1.00 SLC47A1 (0.65) SLC47A1HRH2MEN1SLC22A2LMNA
Cimetidine SCHEMBL11156751 0.99 SLC47A1 (0.64) SLC47A1HRH2MEN1SLC22A2LMNA
Cimetidine SCHEMBL11156749 0.99 SLC47A1 (0.64) SLC47A1HRH2MEN1SLC22A2LMNA
SCHEMBL10338624 0.94 SLC47A1 (0.69) SLC47A1HRH2MEN1SLC22A2LMNA
SCHEMBL11527651 0.93 HRH2 (0.63) SLC47A1HRH2MEN1SLC22A2LMNA
SCHEMBL11527648 0.93 HRH2 (0.63) SLC47A1HRH2MEN1SLC22A2LMNA
Cimetidine SCHEMBL11074155 0.90 HRH2 (0.68) SLC47A1HRH2MEN1SLC22A2LMNA
SCHEMBL11073364 0.90 SLC47A1 (0.55) SLC47A1HRH2MEN1SLC22A2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 320 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4114975-B1 FASCIN-2 (FSCN2) VARIANT AND USE THEREOF REGENERON PHARMA (US) 2026-04-29 EP claimed
EP-3787631-B1 MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS UNIV EMORY (US) 2025-09-10 EP claimed
EP-3793518-B1 AN ORAL TABLET FOR TASTE MASKING OF ACTIVE INGREDIENTS COMPRISING NON-DIRECTLY COMPRESSIBLE SUGAR ALCOHOL PARTICLES FERTIN PHARMA AS (DK) 2025-03-26 EP claimed
EP-3784214-B1 LIQUID ORAL PHARMACEUTICAL DOSAGE FORM JOHNSON & JOHNSON CONSUMER INC (US) 2024-11-13 EP claimed
EP-4088716-B1 AN ORAL TABLET FOR INDUCED SALIVA GENERATION FERTIN PHARMA AS (DK) 2024-10-16 EP claimed
EP-3866770-B1 NOVEL DOSAGE FORM JOHNSON & JOHNSON CONSUMER INC (US) 2024-10-09 EP claimed
EP-3791862-B1 LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS EAGLE BIOLOGICS INC (US) 2024-05-29 EP claimed
EP-3970703-B1 NOVEL NANOPARTICLES USING ANIONIC POLYMER, PREPARATION METHOD AND COMPOSITION THEREOF IMGT CO LTD (KR) 2024-02-07 EP claimed
EP-3682872-B1 LIQUISOFT CAPSULES PATHEON SOFTGELS INC (US) 2024-01-03 EP claimed
EP-4057999-B1 PROCESS FOR PREPARING NANO- OR MICROPARTICLES COMPRISING A CARRIER-POLYMER AND ONE OR MORE BIOLOGICALLY ACTIVE INGREDIENTS EVONIK OPERATIONS GMBH (DE) 2023-12-13 EP claimed
US-11819576-B2 Process for preparing nano-or microparticles comprising a carrier-polymer and one or more biologically active ingredients EVONIK OPERATIONS GMBH (DE) 2023-11-21 US claimed
EP-3836905-B1 NOVEL ORAL COMPOSITION APILLET APS (DK) 2023-10-04 EP claimed
US-20230147853-A1 PROCESS FOR PREPARING NANO- OR MICROPARTICLES COMPRISING A CARRIER-POLYMER AND ONE OR MORE BIOLOGICALLY ACTIVE INGREDIENTS EVONIK OPERATIONS GMBH (DE) 2023-05-11 US claimed
EP-3793534-B1 AN ORAL TABLET FOR DELIVERY OF ACTIVE INGREDIENTS TO THE GASTROINTESTINAL TRACT FERTIN PHARMA AS (DK) 2023-04-05 EP claimed
EP-3972591-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING FLUBENDAZOLE ZEPHAPHARM LTD (GB) 2022-12-28 EP claimed
EP-3337456-B1 LIPOSOMES WITH GINSENOSIDE AS MEMBRANE MATERIAL AND PREPARATIONS AND USE THEREOF SHANGHAI GINPOSOME PHARMATECH CO LTD (CN) 2022-10-26 EP claimed
EP-4061304-A1 MULTI-CHAMBER CONTAINER Rupprecht, Holger (DE) 2022-09-28 EP claimed
EP-4057999-A1 PROCESS FOR PREPARING NANO- OR MICROPARTICLES COMPRISING A CARRIER-POLYMER AND ONE OR MORE BIOLOGICALLY ACTIVE INGREDIENTS Evonik Operations GmbH (DE) 2022-09-21 EP claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
EP-3534880-B1 LIQUID ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING AN HISTAMINE H2-RECEPTOR ANTAGONIST AND AN ANTACID JOHNSON & JOHNSON CONSUMER INC (US) 2022-05-18 EP claimed