SCHEMBL5346129

SCHEMBL5346129

CCCCCCc1cccc(C#C[Si](C)(C)C)c1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.49
PTGS2 P35354 1/20 0.49
TYR P14679 2/20 0.44
BID P55957 3/20 0.43
MCL1 Q07820 3/20 0.43
BCL2L1 Q07817 2/20 0.43
BAK1 Q16611 2/20 0.43
KAT8 Q9H7Z6 2/20 0.43
SAE1 Q9UBE0 2/20 0.43
PPARG P37231 1/20 0.43
PPARA Q07869 1/20 0.43
EP300 Q09472 1/20 0.43
KAT2A Q92830 1/20 0.43
KAT2B Q92831 1/20 0.43
KAT5 Q92993 1/20 0.43
LIPG Q9Y5X9 1/20 0.43
ELANE P08246 2/20 0.40
CTSG P08311 2/20 0.40
KCNH2 Q12809 1/20 0.39
MAPT P10636 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5348955 0.99 ALOX5 (0.50) ALOX5PTGS2TYRBIDMCL1
SCHEMBL5346793 0.94 ALOX5 (0.44) ALOX5PTGS2TYRBIDMCL1
SCHEMBL5351263 0.88 GABRA1 (0.37) ALOX5PTGS2ELANECTSGMAPT
SCHEMBL21164546 0.79 ALOX5 (0.54) ALOX5PTGS2TYRBIDMCL1
SCHEMBL4959229 0.78 ALOX5 (0.68) ALOX5PTGS2TYRBIDMCL1
SCHEMBL11618297 0.78 ALOX5 (0.68) ALOX5PTGS2TYRBIDMCL1
SCHEMBL10926251 0.78 ALOX5 (0.68) ALOX5PTGS2TYRBIDMCL1
SCHEMBL11615237 0.78 ALOX5 (0.68) ALOX5PTGS2TYRBIDMCL1
SCHEMBL199708 0.78 ALOX5 (0.68) ALOX5PTGS2TYRBIDMCL1
SCHEMBL4962037 0.78 ALOX5 (0.68) ALOX5PTGS2TYRBIDMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291692-B2 Polyarylene oxide and method of producing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-11-06 US disclosed
US-20050096452-A1 Polyarylene oxide and method of producing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-05-05 US disclosed