Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL27869488 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT | |
| Isobutanol SCHEMBL28032479 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNATDP1KDM4EMAPT | |
| Butanol SCHEMBL7695797 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT | |
| SCHEMBL5245097 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT | |
| SCHEMBL7784433 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT | |
| Butanol SCHEMBL7695800 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT | |
| Glycerin SCHEMBL3630101 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT | |
| Glycerin SCHEMBL2058190 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT | |
| E968 SCHEMBL2057570 | 0.89 | ALDH1A1 (0.47) | ALDH1A1LMNATDP1KDM4EMAPT | |
| Glycerin SCHEMBL28301031 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169446-B2 | Oxetane compound, actinic ray curable composition, ink composition for ink jet recording, and image formation method | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2007-01-30 | — | — | US | disclosed |
| EP-1486526-B1 | Oxetane compound, actinic ray curable composition, ink composition for ink jet recording, and image formation method | KONICA MINOLTA MED & GRAPHIC (JP) | 2006-08-16 | — | — | EP | disclosed |
| US-20040252171-A1 | Oxetane compound, actinic ray curable composition, ink composition for ink jet recording, and image formation method | KONICA MINOLTA MEDICAL & GRAPHIC, INC. | 2004-12-16 | — | — | US | disclosed |
| EP-1486526-A1 | Oxetane compound, actinic ray curable composition, ink composition for ink jet recording, and image formation method | Konica Minolta Medical & Graphic, Inc. (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-5274147-A | Reacting a manganese(III) salt with a ligand and oxidizing the complex with hydrogen peroxide | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0522817-A1 | Process for preparing manganese complexes | UNILEVER PLC (GB) | 1993-01-13 | — | — | EP | disclosed |