Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.41 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | HINT1 | P49773 | 3/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354398 | 0.92 | KDM4E (0.57) | POLA1ALDH1A1TAS1R3TAS1R1KDM4E | |
| SCHEMBL5353324 | 0.92 | ALDH1A1 (0.51) | POLA1ALDH1A1TAS1R3TAS1R1KDM4E | |
| SCHEMBL5360791 | 0.92 | ALDH1A1 (0.51) | POLA1ALDH1A1TAS1R3TAS1R1KDM4E | |
| SCHEMBL5359289 | 0.92 | ALDH1A1 (0.51) | POLA1ALDH1A1TAS1R3TAS1R1KDM4E | |
| SCHEMBL8445692 | 0.90 | POLA1 (0.67) | POLA1ALDH1A1TAS1R3TAS1R1KDM4E | |
| SCHEMBL5361588 | 0.90 | POLA1 (0.67) | POLA1ALDH1A1TAS1R3TAS1R1KDM4E | |
| SCHEMBL5364897 | 0.87 | POLB (0.60) | POLA1POLBF2P2RY2P2RY4 | |
| SCHEMBL5357283 | 0.87 | POLB (0.60) | POLA1POLBF2P2RY2P2RY4 | |
| SCHEMBL5352650 | 0.87 | POLB (0.60) | POLA1POLBF2P2RY2P2RY4 | |
| SCHEMBL5352210 | 0.87 | POLB (0.60) | POLA1POLBF2P2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307166-B1 | Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis | WELLSTAT THERAPEUTICS CORPORATION (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1157698-A2 | Treatment of inflammatory diseases with oxypurine nucleosides | PRO-NEURON, INC. (US) | 2001-11-28 | — | — | EP | disclosed |
| EP-0771204-A1 | METHODS FOR TREATING SEPSIS OR INFLAMMATORY DISEASES WITH OXYPURINE NUCLEOSIDES | PRO-NEURON, INC. (US) | 1997-05-07 | — | — | EP | disclosed |