Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | PNP | P00491 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TK2 | O00142 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361588 | 1.00 | POLA1 (0.67) | POLA1KDM4EALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL5367337 | 0.97 | POLA1 (0.69) | POLA1KDM4EALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL5347297 | 0.90 | POLA1 (0.55) | POLA1KDM4EALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL16206605 | 0.88 | POLA1 (0.59) | POLA1KDM4ETAS1R3TAS1R1PNP | |
| SCHEMBL6897208 | 0.87 | POLA1 (0.70) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL8535281 | 0.87 | POLA1 (0.70) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL6897217 | 0.87 | POLA1 (0.70) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL29559302 | 0.87 | POLA1 (0.66) | POLA1KDM4ETAS1R3TAS1R1PNP | |
| SCHEMBL890293 | 0.87 | POLA1 (0.66) | POLA1KDM4ETAS1R3TAS1R1PNP | |
| SCHEMBL30208480 | 0.85 | POLA1 (0.61) | POLA1KDM4ETAS1R3TAS1R1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771204-A4 | METHODS FOR TREATING SEPSIS OR INFLAMMATORY DISEASES WITH OXYPURINE NUCLEOSIDES | PRO NEURON INC (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1996004923-A1 | METHODS FOR TREATING SEPSIS OR INFLAMMATORY DISEASES WITH OXYPURINE NUCLEOSIDES | PRO-NEURON, INC. (US) | 1996-02-22 | — | — | WO | disclosed |