Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30718832 | 0.78 | BACE1 (0.52) | KDM4EPOLBKCNH2HRH3HTT | |
| SCHEMBL27150635 | 0.78 | BACE1 (0.52) | KDM4EPOLBKCNH2HRH3HTT | |
| SCHEMBL21416784 | 0.78 | KCNH2 (0.44) | POLBKCNH2HRH3BACE1IDO1 | |
| SCHEMBL4816102 | 0.75 | POLB (0.43) | PLAUKDM4EPOLBMEN1KMT2A | |
| SCHEMBL3858510 | 0.75 | PLAU (0.44) | PLAUKDM4ELMNAPOLBCASP6 | |
| SCHEMBL6852521 | 0.75 | PLAU (0.44) | PLAUKDM4ELMNAPOLBCASP6 | |
| SCHEMBL23062649 | 0.74 | NCF1 (0.35) | KCNH2HRH3ACHEMAPTBACE1 | |
| SCHEMBL27152277 | 0.74 | KCNH2 (0.41) | KDM4EPOLBKCNH2HRH3MEN1 | |
| SCHEMBL1644720 | 0.73 | POLB (0.48) | KDM4EPOLBKCNH2HRH3MEN1 | |
| SCHEMBL29390450 | 0.72 | NPC1 (0.52) | KDM4EPOLBHRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189714-B2 | N-type calcium channel antagonists for the treatment of pain | ASTRAZENECA AB (SE) | 2007-03-13 | — | — | US | disclosed |