Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 6/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30718832 | 0.78 | BACE1 (0.52) | KCNH2HRH3IDO1BACE1POLB | |
| SCHEMBL27150635 | 0.78 | BACE1 (0.52) | KCNH2HRH3IDO1BACE1POLB | |
| SCHEMBL5347416 | 0.78 | PLAU (0.55) | KCNH2HRH3IDO1BACE1POLB | |
| SCHEMBL27152277 | 0.74 | KCNH2 (0.41) | KCNH2HRH3IDO1BACE1POLB | |
| SCHEMBL1644720 | 0.73 | POLB (0.48) | KCNH2HRH3POLBESR2 | |
| SCHEMBL29390450 | 0.72 | NPC1 (0.52) | HRH3IDO1BACE1POLB | |
| SCHEMBL902873 | 0.72 | NPC1 (0.52) | HRH3IDO1BACE1POLB | |
| SCHEMBL31458446 | 0.71 | ALDH1A1 (0.50) | — | |
| SCHEMBL30718756 | 0.69 | KCNH2 (0.49) | KCNH2HRH3IDO1POLBPDE2A | |
| SCHEMBL27144359 | 0.69 | KCNH2 (0.49) | KCNH2HRH3IDO1POLBPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |