Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 9/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | NMT2 | O60551 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15022112 | 0.86 | ALDH1A1 (0.50) | NOTUMHCRTR2ALDH1A1PIK3CD | |
| SCHEMBL5347384 | 0.85 | NEK2 (0.51) | NOTUMHCRTR2 | |
| SCHEMBL5361060 | 0.78 | IDH1 (0.45) | POLBTDP1L3MBTL1NMT2NMT1 | |
| SCHEMBL5779331 | 0.76 | ACACB (0.51) | POLBTDP1L3MBTL1NMT2NMT1 | |
| SCHEMBL5351528 | 0.75 | NMT2 (0.43) | POLBTDP1L3MBTL1NMT2NMT1 | |
| SCHEMBL30919884 | 0.74 | SMN1; SMN2 (0.41) | HCRTR2ABL1BCRALDH1A1PIK3CD | |
| SCHEMBL30919755 | 0.73 | KMT2A (0.43) | TDP1L3MBTL1HCRTR2ALDH1A1MAPT | |
| SCHEMBL4076212 | 0.73 | KDM4E (0.48) | NOTUMALDH1A1 | |
| SCHEMBL12184895 | 0.71 | ALDH1A1 (0.55) | TDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL22856272 | 0.71 | PDE10A (0.47) | POLBHCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157122-A | Imidazo [1,2-a ] pyridine compounds and their use in therapy | 帝国理工学院创新有限公司 | 2023-05-23 | — | — | CN | disclosed |
| WO-2022058745-A9 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022058745-A2 | NOVEL COMPOUNDS AND THEIR USE IN THERAPY | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-03-24 | — | — | WO | disclosed |
| US-7244735-B2 | Heterocyclic protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INC. (US) | 2007-07-17 | — | — | US | disclosed |
| EP-1697375-A2 | HETEROCYCLIC PROTEIN KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20050245499-A1 | Heterocyclic protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2005-11-03 | — | — | US | disclosed |
| WO-2005068468-A2 | HETEROCYCLIC PROTEIN KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS, INC. (US) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245499-A1 | Heterocyclic protein kinase inhibitors and uses thereof | JAK1, PRKCQ, SKP1 | POLB 2033/4885TDP1 1789/4885L3MBTL1 1532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.